| Bioactivity | Keap1-Nrf2-IN-5 (compound 1) is a potent Keap1-Nrf2 PPI (Keap1-Nrf2 protein−protein interaction) inhibitor with an IC50 of 4.1 µM, Kd of 3.7 µM[1]. |
| Target | IC50: 4.1 µM (Keap1-Nrf2); Kd: 3.7 µM |
| Name | Keap1-Nrf2-IN-5 |
| CAS | 2696272-70-3 |
| Formula | C23H30N4O6S |
| Molar Mass | 490.57 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Begnini F, et al. Importance of Binding Site Hydration and Flexibility Revealed When Optimizing a Macrocyclic Inhibitor of the Keap1-Nrf2 Protein-Protein Interaction. J Med Chem. 2022 Feb 24;65(4):3473-3517. |
Keap1-Nrf2-IN-5
CAS: 2696272-70-3 F: C23H30N4O6S W: 490.57
Keap1-Nrf2-IN-5 (compound 1) is a potent Keap1-Nrf2 PPI (Keap1-Nrf2 protein−protein interaction) inhibitor with an IC50
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