Keap1-Nrf2-IN-15

CAS: 2456295-45-5 F: C39H35N3O12S2 W: 801.84

Keap1-Nrf2-IN-15 (Compound 24a) is a potent Keap1-Nrf2 protein-protein interaction inhibitor with IC50s of 77 nM and 2.5

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Bioactivity	Keap1-Nrf2-IN-15 (Compound 24a) is a potent Keap1-Nrf2 protein-protein interaction inhibitor with IC50s of 77 nM and 2.5 nM in FP assay and TR-FRET assay, respectively[1].
Invitro	Keap1-Nrf2-IN-15 (Compound 24a) 与 Keap1 蛋白结合[1]。Keap1-Nrf2-IN-15 (10 and 100 μM; 24 h) 导致 Nrf2 靶基因 (HMOX1、GSTM3、NQO1) 在 NCM460D 细胞中显著诱导[1]。
Name	Keap1-Nrf2-IN-15
CAS	2456295-45-5
Formula	C39H35N3O12S2
Molar Mass	801.84
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Abed DA, et al. Optimization of the C2 substituents on the 1,4-bis(arylsulfonamido)naphthalene-N,N'-diacetic acid scaffold for better inhibition of Keap1-Nrf2 protein-protein interaction. Eur J Med Chem. 2023 Apr 5;252:115302.