| Bioactivity | Keap1-Nrf2-IN-12 is a potent Keap1-Nrf2 inhibitor with an IC50 value of 2.30 µM. Keap1-Nrf2-IN-12 shows metabolic stability in human liver microsomes[1]. |
| Target | IC50: 2.30 µM (Keap1-Nrf2). |
| Invitro | Keap1-Nrf2-IN-12 (compound 9a) shows metabolic stability in human liver microsomes with slight changes (97.7% remained) after 90 min of incubation[1]. |
| Name | Keap1-Nrf2-IN-12 |
| CAS | 2250082-04-1 |
| Formula | C26H28N2O10S2 |
| Molar Mass | 592.64 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Abed DA, et al. Discovery of disubstituted xylylene derivatives as small molecule direct inhibitors of Keap1-Nrf2 protein-protein interaction. Bioorg Med Chem. 2020 Mar 15;28(6):115343. |
Keap1-Nrf2-IN-12
CAS: 2250082-04-1 F: C26H28N2O10S2 W: 592.64
Keap1-Nrf2-IN-12 is a potent Keap1-Nrf2 inhibitor with an IC50 value of 2.30 µM. Keap1-Nrf2-IN-12 shows metabolic stabi
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