| Bioactivity | Keap1-Nrf2-IN-10 (compound 15) is a potent NQO1 inducer. Keap1-Nrf2-IN-10 inhibits oxidative stress by decreasing the levels of MDA, ROS, NQO1 in the liver for gamma-irradiated mice. Keap1-Nrf2-IN-10 improves the survival of gamma-irradiated mice[1]. |
| Target | NQO1 |
| Name | Keap1-Nrf2-IN-10 |
| CAS | 2445349-54-0 |
| Formula | C25H22I2N4O7S2 |
| Molar Mass | 808.40 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Soliman AM, et al. Radiomodulatory effect of a non-electrophilic NQO1 inducer identified in a screen of new 6, 8-diiodoquinazolin-4(3H)-ones carrying a sulfonamide moiety. Eur J Med Chem. 2020 Aug 15;200:112467. |
Keap1-Nrf2-IN-10
CAS: 2445349-54-0 F: C25H22I2N4O7S2 W: 808.40
Keap1-Nrf2-IN-10 (compound 15) is a potent NQO1 inducer. Keap1-Nrf2-IN-10 inhibits oxidative stress by decreasing the le
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