Kazusamycin B_product_DataBase

Bioactivity	Kazusamycin B is an antibiotic that could be isolated from the fermentation broth of Streptomyces sp. No. 81-484. Kazusamycin B inhibits cell growth and arrests cell cycle at G1 phase. Kazusamycin B can be used in research of cancer[1][2].
Invitro	Kazusamycin B (PD 124895; 5 ng/mL; 24 h; 1210 cells) 具有时间依赖性的细胞毒性，使细胞周期停滞在 G1 期[2]。Kazusamycin B (5-50 ng/mL; 0-6 h; 1210 cells) 适度抑制 RNA 合成，但特异性抑制 2 小时[2]。 Cell Cycle Analysis[2] Cell Line:
Name	Kazusamycin B
CAS	107140-30-7
Formula	C32H46O7
Molar Mass	542.70
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Funaishi K, et, al. Kazusamycin B, a novel antitumor antibiotic. J Antibiot (Tokyo). 1987 Jun;40(6):778-85. [2]. Takamiya K, et, al. The effect of kazusamycin B on the cell cycle and morphology of cultured L1210 cells. J Antibiot (Tokyo). 1988 Dec;41(12):1854-61.

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