| Bioactivity | Kartogenin (KGN) sodium is an inducer of chondrogenic tissue formation (EC50: 100 nM). Kartogenin sodium induces chondrogenesis by binding to fibrin A, disrupting its interaction with the transcription factor core binding factor beta subunit (CBFβ), and by modulating the CBFβ-RUNX1 transcriptional program. Kartogenin sodium also promotes tendon-bone junction (TBJ) wound healing by stimulating collagen synthesis. Kartogenin sodium is widely used in cell-free therapy in the field of regeneration for cartilage regeneration and protection, tendon-bone healing, wound healing and limb development. Kartogenin sodium promotes cartilage repair, coordinates limb development, and is also used in osteoarthritis (OA) research[1][2][3][4]. |
| Invitro | Kartogenin sodium（100 nM；72 h）诱导原代 hMSC 中软骨细胞结节的形成[1]。Kartogenin sodium（10 nM-10 μM；72 h）可增加 hMSC 中软骨细胞特异性基因的表达[1]。Kartogenin sodium（0.12-10 μM；48 h）可抑制原代牛关节软骨细胞中细胞因子诱导的一氧化氮 (NO) 和糖胺聚糖 (GAG) 释放[1]。Kartogenin sodium（50-5000 nM；2 wk）以浓度依赖性方式诱导 BMSC 的软骨分化[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Kartogenin sodium 相关抗体: |
| In Vivo | Kartogenin sodium（10 μM，溶于 4μL 盐水中；在第 7 天和第 21 天处理）可促进胶原酶 VII 诱导的小鼠 OA 模型中的软骨修复[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| CAS | 1401168-39-5 |
| Formula | C20H14NNaO3 |
| Molar Mass | 339.32 |
| Appearance | 固体 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) |
| Reference | [1]. Johnson K, et, al. A stem cell-based approach to cartilage repair. Science. 2012 May 11;336(6082):717-21. [2]. Liu F, et, al. A novel kartogenin-platelet-rich plasma gel enhances chondrogenesis of bone marrow mesenchymal stem cells in vitro and promotes wounded meniscus healing in vivo. Stem Cell Res Ther. 2019 Jul 8;10(1):201. [3]. Cai J, Zhang L, Chen J, et al. Kartogenin and its application in regenerative medicine[J]. Current medical science, 2019, 39(1): 16-20. [4]. Zhang J, Wang J H C. Kartogenin induces cartilage-like tissue formation in tendon–bone junction[J]. Bone research, 2014, 2(1): 1-10. |
Kartogenin sodium
CAS: 1401168-39-5 F: C20H14NNaO3 W: 339.32
Kartogenin (KGN) sodium is an inducer of chondrogenic tissue formation (EC50: 100 nM). Kartogenin sodium induces chondro
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