Bioactivity | Kalata B7 is a cyclotide that can be isolated from Oldenlandia affinis DC (Rubiaceae) and possesses membrane-permeating capabilities. Kalata B7 is also a partial agonist of oxytocin- and vasopressin V1a- receptors[1][2]. |
CAS | 339532-29-5 |
Sequence | Arg-Asn-Gly-Leu-Pro-Val-Cys-Gly-Glu-Thr-Cys-Thr-Leu-Gly-Thr-Cys-Tyr-Thr-Gln-Gly-Cys-Thr-Cys-Ser-Trp-Pro-Ile-Cys-Lys (Disulfidebridge:Cys7-Cys21;Cys11-Cys23;Cys16-Cys28) |
Shortening | RNGLPVCGETCTLGTCYTQGCTCSWPICK (Disulfidebridge:Cys7-Cys21;Cys11-Cys23;Cys16-Cys28) |
Formula | C128H196N36O40S6 |
Molar Mass | 3071.53 |
Transport | Room temperature in continental US; may vary elsewhere. |
Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Reference | [1]. Strömstedt AA, et al. Selective membrane disruption by the cyclotide kalata B7: complex ions and essential functional groups in the phosphatidylethanolamine binding pocket. Biochim Biophys Acta. 2016;1858(6):1317-1327. [2]. Taghizadeh MS, et al. Discovery of the cyclotide caripe 11 as a ligand of the cholecystokinin-2 receptor. Sci Rep. 2022 Jun 2;12(1):9215. |