| Bioactivity | KY02111 is a canonical WNT signaling (β-catenin) inhibitor which promotes differentiation of hPSCs to cardiomyocytes. KY02111 can be used for the research of human cardiomyocyte regeneration[1]. | ||||||||||||
| Invitro | KY02111 promotes differentiation by inhibiting WNT signaling in hPSCs[1].KY02111 induces cardiomyocytes expressed the cardiac markers, αMHC, NKH2.5, and HCN4[1].KY02111 (1-10 μM; 12 hours, 24 hours) reduces WNT signaling in both IMR90-1 cells and HEK293 cells in a dose-dependent manner[1].KY02111 treatment with WNT signaling modulators produces robust cardiac differentiation of hPSCs in a xeno-free, defined medium, devoid of serum and any kind of recombinant cytokines and hormones, such as BMP4, Activin A, or insulin[1]. | ||||||||||||
| Name | KY02111 | ||||||||||||
| CAS | 1118807-13-8 | ||||||||||||
| Formula | C18H17ClN2O3S | ||||||||||||
| Molar Mass | 376.86 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Minami I, et al. A small molecule that promotes cardiac differentiation of human pluripotent stem cells under defined, cytokine- and xeno-free conditions. Cell Rep. 2012 Nov 29;2(5):1448-60. |
KY02111
CAS: 1118807-13-8 F: C18H17ClN2O3S W: 376.86
KY02111 is a canonical WNT signaling (β-catenin) inhibitor which promotes differentiation of hPSCs to cardiomyocytes. K
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