| Bioactivity | KY 234 is an orally effective inhibitor that targets thromboxane A2 production, with an IC50 of 5 μM. KY 234 significantly inhibits leukotriene D4 (LTD4), histamine, and antigen-induced bronchoconstriction in guinea pigs, with IC50 values of 6.0 mg/kg, 2.5 mg/kg, and 6.3 mg/kg, respectively[1]. |
| Target | Thromboxane A2 receptor |
| CAS | 172544-75-1 |
| Formula | C33H34N5NaO2 |
| Molar Mass | 555.65 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. KAMIYA S, et al. Thromboxane A2 synthetase inhibitors with histamine H1-blocking activity: synthesis and evaluation of a new series of indole derivatives[J]. Chemical and pharmaceutical bulletin, 1995, 43(10): 1692-1695. |