| Bioactivity | KV1.3-IN-1 (Compound trans-18) is a KV1.3 channel inhibitor (IC50: 230 nM and 26.12 nM in Ltk? cells and PHA-activated T-lymphocytes respectively). KV1.3-IN-1 impairs intracellular Ca2+ signaling. KV1.3-IN-1 inhibits T-cell activation, proliferation, and colony formation[1]. |
| Name | KV1.3-IN-1 |
| Formula | C23H30N2O4S |
| Molar Mass | 430.56 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Gubič Š, et al. Immunosuppressive effects of new thiophene-based KV1.3 inhibitors. Eur J Med Chem. 2023 Jun 25;259:115561. |