| Bioactivity | KU-0058948 is a specific and potent PARP1 inhibitor with an IC50 of 3.4 nM. KU-0058948 induces cell cycle arrest and apoptosis of primary myeloid leukemic cells and myeloid leukemic cell lines[1][2]. |
| CAS | 763111-49-5 |
| Formula | C21H21FN4O2 |
| Molar Mass | 380.42 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Hannah Farmer, et al. Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature. 2005 Apr 14;434(7035):917-21. [2]. Gaymes TJ, et al. Inhibitors of poly ADP-ribose polymerase (PARP) induce apoptosis of myeloid leukemic cells: potential for therapy of myeloid leukemia and myelodysplastic syndromes. Haematologica. 2009 May;94(5):638-46. |
KU-0058948
CAS: 763111-49-5 F: C21H21FN4O2 W: 380.42
KU-0058948 is a specific and potent PARP1 inhibitor with an IC50 of 3.4 nM. KU-0058948 induces cell cycle arrest and apo
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.