| Bioactivity | KTX-582 is a potent IRAK4 degrader with DC50 values of 4 nM and 5 nM for IRAK4 and Ikaros, respectively. KTX-582 can induce apoptosis in MYD88MT DLBCL, and is efficient to induce in vivo tumor regressions in lymphoma model[1][2][3]. |
| Invitro | KTX-582 (compound I-41) degrades IRAK4 in whole blood monocyte and lymphocyte with IC50s of <0.05 μM[4].KTX-582 inhibits IRAK4 in human whole blood LPS TNFα with an IC50 of 0.05~1 μM[4]. |
| Name | KTX-582 |
| CAS | 2573298-13-0 |
| Formula | C45H51F3N8O7 |
| Molar Mass | 872.93 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
KTX-582
CAS: 2573298-13-0 F: C45H51F3N8O7 W: 872.93
KTX-582 is a potent IRAK4 degrader with DC50 values of 4 nM and 5 nM for IRAK4 and Ikaros, respectively. KTX-582 can ind
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