KSL 128114_product_DataBase

Bioactivity	KSL 128114, a peptide inhibitor of syntenin, binds the PDZ1 domain of syntenin with nanomolar affinity. KSL 128114 is resistant toward degradation in human plasma and mouse hepatic microsomes and displays a global PDZ domain selectivity for syntenin[1].
Invitro	KSL-128114 (~20 μM) 对原发性GBM细胞活力具有抑制作用，并在患者来源的异种移植小鼠模型中显著延长了生存时间。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> KSL 128114 相关抗体:
CAS	2757292-12-7
Sequence	Ac-{d-Arg}-Arg-{d-Arg}-Gly-{d-Arg}-Lys-{d-Lys}-Arg-{d-Arg}-Ser-His-Trp-Tle-Chg-Asp-Ile
Shortening	Ac-{d-Arg}-R-{d-Arg}-G-{d-Arg}-K-{d-Lys}-R-{d-Arg}-SHW-{Tle-Chg}-DI
Formula	C96H165N39O21
Molar Mass	2201.59
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Linda M Haugaard-Kedström, et al. A High-Affinity Peptide Ligand Targeting Syntenin Inhibits Glioblastoma. J Med Chem. 2021 Feb 11;64(3):1423-1434.

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