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KSL 128114

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Bioactivity KSL 128114, a peptide inhibitor of syntenin, binds the PDZ1 domain of syntenin with nanomolar affinity. KSL 128114 is resistant toward degradation in human plasma and mouse hepatic microsomes and displays a global PDZ domain selectivity for syntenin[1].
Invitro KSL-128114 (~20 μM) 对原发性GBM细胞活力具有抑制作用，并在患者来源的异种移植小鼠模型中显著延长了生存时间。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> KSL 128114 相关抗体:
CAS 2757292-12-7
Sequence Ac-{d-Arg}-Arg-{d-Arg}-Gly-{d-Arg}-Lys-{d-Lys}-Arg-{d-Arg}-Ser-His-Trp-Tle-Chg-Asp-Ile
Shortening Ac-{d-Arg}-R-{d-Arg}-G-{d-Arg}-K-{d-Lys}-R-{d-Arg}-SHW-{Tle-Chg}-DI
Formula C96H165N39O21
Molar Mass 2201.59
Transport Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Reference [1]. Linda M Haugaard-Kedström, et al. A High-Affinity Peptide Ligand Targeting Syntenin Inhibits Glioblastoma. J Med Chem. 2021 Feb 11;64(3):1423-1434.
How to place a order： 1) Contact us at: Whatsapp:+86-(0)-18753388868 or peptidedb@qq.com;
2) Provide us peptides information including Sequence, Purity, Quantity and modification(If necessary, we agree to sign confidential agreement with you before you provide these information), we will make you a quotes within 30 minutes;
3) Place us a purchaser order, we can send you a sales contract too if you need;
4) Start synthesis, and we will inform you the updates of synthesis in time;
5) Arrange shippment, HPLC analysis, MS spectrum will be shipped along the peptides too;
6) Refund all pre-payment(if pre-pay us) if we failed to synthesize any of them;
7) After-sale service: Contact us anytime if you have any problem when you use the peptides, and we will reply you as soon as possible.
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