| Bioactivity | KSI-6666 is an orally active, competitive antagonist for sphingosine 1-phosphate receptor 1 (S1PR1), with an IC50 of 6.4 nM. KSI-6666 exhibits anti-inflammatory efficacy in autoimmune encephalomyelitis model and T cell transfer colitis model[1]. |
| CAS | 1807873-14-8 |
| Formula | C23H26ClF3N2O2 |
| Molar Mass | 454.91 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Maruyama Y, et al. Pseudoirreversible inhibition elicits persistent efficacy of a sphigosine-1-phosphate receptor-1 antagonist[J]. bioRxiv, 2023: 2023.05. 08.539826. |
KSI-6666
CAS: 1807873-14-8 F: C23H26ClF3N2O2 W: 454.91
KSI-6666 is an orally active, competitive antagonist for sphingosine 1-phosphate receptor 1 (S1PR1), with an IC50 of 6.4
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