| Bioactivity | KS370G is an orally active hypoglycemic and cardiovascular protective agent. KS370G improves left ventricular hypertrophy and function in pressure-overload mice heart. KS370G reduces renal obstructive nephropathy[1][2]. |
| In Vivo | KS370G (1 mg/kg; oral; once daily for 8 weeks) 通过降低压力过载小鼠心脏 ERK、AKT 和 GSK3β 的磷酸化，改善左心室功能，抑制心脏肥厚[1]。 KS370G (10 mg/kg; oral; once daily for 13 days) 通过减少小鼠炎症和氧化应激减轻单侧输尿管梗阻引起的肾纤维化[2]。 Animal Model: |
| Name | KS370G |
| CAS | 105955-01-9 |
| Formula | C17H17NO3 |
| Molar Mass | 283.32 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Weng YC, et al. KS370G, a synthetic caffeamide derivative, improves left ventricular hypertrophy and function in pressure-overload mice heart. Eur J Pharmacol. 2012 Jun 5;684(1-3):108-15. [2]. Chuang ST, et al. KS370G, a caffeamide derivative, attenuates unilateral ureteral obstruction-induced renal fibrosis by the reduction of inflammation and oxidative stress in mice. Eur J Pharmacol. 2015 Mar 5;750:1-7. |