| Bioactivity | KS106 is a potent ALDH inhibitor with IC50s of 334, 2137, 360 nM for ALDH1A1, ALDH2, and ALDH3A1, respectively. KS106 shows antiproliferative and anticancer effects with low low toxic.KS106 significantly increases ROS activity, lipid peroxidation and toxic aldehyde accumulation. KS106 induces apoptosis and cell cycle arrest at the G2/M phase[1]. |
| Invitro | KS106 (compound 3h) (0-100 µM; 72 h) shows anti-proliferative activity with IC50s of 5.7, 5.7, 5.7, 4.9, 1.5, 2.6, 1.6, 1.7, 2.2, 20.7 µM for UACC 903, 1205 Lu, HCT116, HT29, NCIH929, U266, RPMI8226, MM.1R, MM.1S, FF2441 cells, respectively[1].KS106 (5 µM, 24 h) induces apoptosis and cell cycle arrest at the G2/M phase[1]. Apoptosis Analysis[1] Cell Line: |
| Name | KS106 |
| CAS | 2408477-50-7 |
| Formula | C18H15BrF3N3O2S |
| Molar Mass | 474.29 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) |
KS106
CAS: 2408477-50-7 F: C18H15BrF3N3O2S W: 474.29
KS106 is a potent ALDH inhibitor with IC50s of 334, 2137, 360 nM for ALDH1A1, ALDH2, and ALDH3A1, respectively. KS106 sh
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