| Bioactivity | KS-58 is a KRpep-2d (HY-P3277) derivative. KS-58 is a K-Ras (G12D) inhibitory peptide that selectively binds K-Ras. KS-58 can enter cells and block intracellular Ras interaction with effector proteins. KS-58 inhibits the proliferation of tumor cells and has antitumor activity[1][2]. |
| CAS | 2549046-46-8 |
| Formula | C64H89FN12O14S2 |
| Molar Mass | 1333.59 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Sakamoto K, et al. Nanoformulation of the K-Ras(G12D)-inhibitory peptide KS-58 suppresses colorectal and pancreatic cancer-derived tumors. Sci Rep. 2023 Jan 10;13(1):518. [2]. Sakamoto K, et al Generation of KS-58 as the first K-Ras(G12D)-inhibitory peptide presenting anti-cancer activity in vivo. Sci Rep. 2020 Dec 10;10(1):21671. |
KS-58
CAS: 2549046-46-8 F: C64H89FN12O14S2 W: 1333.59
KS-58 is a KRpep-2d (HY-P3277) derivative. KS-58 is a K-Ras (G12D) inhibitory peptide that selectively binds K-Ras. KS-5
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