| Bioactivity | KRpep-2d is a potent K-Ras inhibitor and inhibits proliferation of K-Ras-driven cancer cells. KRpep-2d can be used for cancer research[1]. | ||||||
| Invitro | KRpep-2d has cyclic structure with importance for K-Ras inhibitory activity. Leu77 , Ile9 and Asp12 are critical amino acid residues for the K-Ras inhibitory activity of KRpep-2d[1]. KRpep-2d (10-30 μM) has inhibitory activity of A427 cells with the proliferation rates of 68.3% (10 μM) and 48.3% (10 μM)[1]. | ||||||
| Name | KRpep-2d | ||||||
| CAS | 2098181-84-9 | ||||||
| Shortening | Ac-RRRRCPLYISYDPVCRRRR-NH2 (disulfide bridge: Cys5-Cys15) | ||||||
| Formula | C109H183N43O25S2 | ||||||
| Molar Mass | 2560.02 | ||||||
| Appearance | Solid | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Sealed storage, away from moisture and light, under nitrogen
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen) |
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| Reference | [1]. Niida A, et al. Investigation of the structural requirements of K-Ras(G12D) selective inhibitory peptide KRpep-2d using alanine scans and cysteine bridging. Bioorg Med Chem Lett. 2017 Jun 15;27(12):2757-2761. |
KRpep-2d
CAS: 2098181-84-9 F: C109H183N43O25S2 W: 2560.02
KRpep-2d is a potent K-Ras inhibitor and inhibits proliferation of K-Ras-driven cancer cells. KRpep-2d can be used for c
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