| Bioactivity | KRL74 is a cyclic peptide inhibitor for interaction between the p6 domain of the HIV Gag protein and the UEV domain of the human TSG101 protein(p6/UEV) with an IC50 of 5.44 μM and a Kd of 11.9 μM. KRL74 inhibits the budding process of HIV from host cells with an IC50 of 2 μM in virus-like particle (VLP) budding assay[1]. |
| CAS | 2423969-43-9 |
| Sequence | cyclo(Ser-Gly-Trp-Ile-{Phe<4-Cl>}-Trp-Ala-Val) |
| Shortening | cyclo(SGWI-{Phe<4-Cl>}-WAV) |
| Formula | C50H61ClN10O9 |
| Molar Mass | 981.53 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Lennard KR, et al., Development of a Cyclic Peptide Inhibitor of the p6/UEV Protein-Protein Interaction. ACS Chem Biol. 2019 Sep 20;14(9):1874-1878. |
KRL74
CAS: 2423969-43-9 F: C50H61ClN10O9 W: 981.53
KRL74 is a cyclic peptide inhibitor for interaction between the p6 domain of the HIV Gag protein and the UEV domain of t
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