| Bioactivity | KRIBB11 is an inhibitor of Heat shock factor 1 (HSF1), with IC50 of 1.2 μM. | ||||||||||||
| Invitro | KRIBB11 blocks the induction of HSF1 downstream target proteins such as HSP27 and HSP70. KRIBB11 induces growth arrest and apoptosis of HCT-116 cells. KRIBB11 inhibits HSF1-dependent recruitment of p-TEFb (positive transcription elongation factor b) to the hsp70 promoter[1]. PARP and caspase-3 cleavage is increased in cells treated with KRIBB11. Incubating RKO with KRIBB11, shows a toxic threshold of about 10 µM, and an IC50 of 20-30 µM[2]. | ||||||||||||
| Name | KRIBB11 | ||||||||||||
| CAS | 342639-96-7 | ||||||||||||
| Formula | C13H12N6O2 | ||||||||||||
| Molar Mass | 284.27 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
|