KRAS G12D inhibitor 22_product_DataBase

Bioactivity	KRAS G12D inhibitor 22 (compound 6) is a inhibitor of KRAS mutation. KRAS G12D inhibitor 22 has high activity(IC50＜100 nM), good selectivity and low toxicity.KRAS G12D inhibitor 22 can be used in breast cancer research[1].
Invitro	KRAS G12D inhibitor 22 (0.08-20 μM; 72 h) 对 AGS 细胞生长有良好的抑制作用(IC50＜500 nM)[1]。KRAS G12D inhibitor 22 对 KRAS G12D 蛋白有较高的抑制作用(IC50 0 --> KRAS G12D inhibitor 22 相关抗体: Cell Proliferation Assay[1] Cell Line:
In Vivo	KRAS G12D inhibitor 22 (3 和 5 mg/kg； i.v. 和 i.p.； 0-24 h) 单次给药后能够达到抑制肿瘤细胞生长的药物起效浓度，且具有较好的生物利用度在 SD 大鼠体内。[1]。Pharmacokinetic Analysis in Male SD ratl[1]Route
Formula	C35H32F4N6O2
Molar Mass	644.66
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Huang Qi, et al. Pyrimidine fused ring compound, preparation method therefor, and use thereof.WO2024061365. 2023-09-22

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