| Bioactivity | KRAS G12C inhibitor 69 (Compound K09) is the inhibitor for mutant RAS protein KRASG12C with an IC50 of 4.36 nM. KRAS G12C inhibitor 69 inhibits the ERK phosphorylation in NCI-H358 and MIA-PACA-2 with an IC50 of 12 nM and 7 nM. KRAS G12C inhibitor 69 inhibits the proliferation of cancer cell NCI-H358 and MIA-PACA-2 with IC50 of 3.15 nM and 2.33 nM[1]. |
| Formula | C29H29ClF3N5O3 |
| Molar Mass | 588.02 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Liu N, et al. Discovery of Quinazoline Derivatives as Potent KRASG12C Inhibitors[J]. ChemistrySelect, 2024, 9(39): e202402267. |
KRAS G12C inhibitor 69
CAS: F: C29H29ClF3N5O3 W: 588.02
KRAS G12C inhibitor 69 (Compound K09) is the inhibitor for mutant RAS protein KRASG12C with an IC50 of 4.36 nM. KRAS G12
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