KR-32568_product_DataBase

Bioactivity	KR-32568 is a sodium/hydrogen exchanger-1 (NHE-1) inhibitor with an IC50 of 230 nM. KR-32568 has cardioprotective effects[1][2].
Target	IC50: 230 nM (NHE-1)
Invitro	KR-32568 (10 nM-1 μM) 以浓度依赖性方式抑制 NHE-1 介导的兔富血小板血浆细胞内酸化引起的血小板肿胀，IC50 值为 24 nM[1]。
In Vivo	KR-32568（0.1-1.0 mg/kg；i.v.；一次）对大鼠发挥有效的心脏保护作用，例如减少梗塞面积，并显着减少室性早搏的总数[1]。 Animal Model:
Name	KR-32568
CAS	852146-73-7
Formula	C13H12FN3O2
Molar Mass	261.25
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Hui-Yul Roh, et al. Cardioprotective effects of [5-(2-methyl-5-fluorophenyl)furan-2-ylcarbonyl]guanidine (KR-32568) in an anesthetized rat model of ischemia and reperfusion heart injury. Pharmacology. 2005 Dec;75(1):37-44. [2]. Sunkyung Lee, et al. (5-Arylfuran-2-ylcarbonyl)guanidines as cardioprotectives through the inhibition of Na+/H+ exchanger isoform-1. J Med Chem. 2005 Apr 21;48(8):2882-91.

PeptideDB