| Bioactivity | KPC-2-IN-2 (Compound 6c) is a potent Klebsiella pneumoniae carbapenemase (KPC-2) inhibitor (Ki=0.038 μM). KPC-2-IN-2 can enhance the activity of cefotaxime in KPC-2 expressing Escherichia coli[1]. |
| Target | IC50: 0.038 μM (KPC-2) |
| Invitro | KPC-2-IN-2 (5 and 50 μg/mL; 24 h) treatment shows excellent tolerance in HEK-293[1]. Cell Cytotoxicity Assay[1] Cell Line: |
| Name | KPC-2-IN-2 |
| Formula | C12H10BN3O2S |
| Molar Mass | 271.10 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Jingyuan Zhou, et al. Triazole-substituted phenylboronic acids as tunable lead inhibitors of KPC-2 antibiotic resistance. Eur J Med Chem. 2022 Jun 28;240:114571. |