| Bioactivity | KP 544 is a potent neurotrophic protein enhancer that amplifies nerve growth factor (NGF)-induced neurite outgrowth of PC12 cells and SH-SY5Y neuroblastoma cells. KP544 also enhances choline acetyltransferase activity. KP 544 selectively interact in the differentiation pathway downstream of MAPK in a manner that amplifies nerve growth factor and cyclic AMP effects and is also neuroprotective[1]. |
| CAS | 393856-87-6 |
| Formula | C18H19ClN4O |
| Molar Mass | 342.82 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Fyfe J A, et al. KP544 amplifies the effects of nerve growth factor on cell differentiation and is neuroprotective[J]. Drug development research, 2004, 62(1): 49-59. |