| Bioactivity | KOTX1 is an orally active and selective ALDH1A3 inhibitor. KOTX1 improves glucose tolerance, insulin secretion and blood sugar levels in diabetic mouse models[1]. |
| Invitro | KOTX1 (0-1 μM) 在 A375 细胞中，对 ALDH1A3 的 IC50 为 5.14 nM[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> KOTX1 相关抗体: |
| In Vivo | KOTX1 (40 mg/kg；灌胃；4 周) 在糖尿病小鼠模型中具有改善作用[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| CAS | 1788963-83-6 |
| Formula | C17H16FN3O2 |
| Molar Mass | 313.33 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Son J, et al. Genetic and pharmacologic inhibition of ALDH1A3 as a treatment of β-cell failure. Nat Commun. 2023 Feb 2;14(1):558. |