| Bioactivity | KN-92 is an inactive derivative of KN-93, without CaM kinase inhibitory activity. KN-92 is intended to be used as a control compound in studies designed to elucidate the antagonist activities of KN-93. KN-93 is a cell-permeable, reversible and competitive CaMKII inhibitor[1][2]. |
| Invitro | KN-93 (5-50 μM; 24 hours) inhibits LX-2 cell growth and KN-92 (5-50 μM; 24 hours) is ineffective in blocking cell growth[2].The analysis of cell cycle regulator expression reveals that KN-93 rather than KN-92 reduces the expression of p53 and p21[2]. Cell Viability Assay[2] Cell Line: |
| Name | KN-92 |
| CAS | 176708-42-2 |
| Formula | C24H25ClN2O3S |
| Molar Mass | 456.98 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Smyth JT, et al. Inhibition of the inositol trisphosphate receptor of mouse eggs and A7r5 cells by KN-93 via a mechanism unrelated to Ca2+/calmodulin-dependent protein kinase II antagonism. J Biol Chem. 2002;277(38):35061-35070. [2]. An P, et al. KN-93, a specific inhibitor of CaMKII inhibits human hepatic stellate cell proliferation in vitro. World J Gastroenterol. 2007;13(9):1445-1448. |