KMG-104_product_DataBase

Bioactivity

KMG-104 is a highly selective fluorescent Mg2+ probe. KMG-104 has been used widely and revealed Mg2+ mobilization in cytoplasm in various types of cells[1].

Invitro

KMG-104 is useful for confocal laser scanning microscopy because it is excited at 490 nm, and emitted fluorescence around 510 nm. Fluorescent intensity of KMG-104 increases with [Mg] increase, and it shows no response to Na, K, and Ca; the dissociation constant (Kd) for Mg is 3 mM. KMG-104 is able to trace only [Mg] change inphysiological conditions[2].PC12 cells are loaded with a novel Mg indicator KMG-104 and Ca indicator fura-2, and intracellular Mg is studied in the endoplasmic reticulums (ERs), mitochondria, and Mg-ATP[2].

Name

KMG-104

CAS

852057-94-4

Formula

C23H11F2NO6

Molar Mass

435.33

Appearance

Solid

Transport

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Reference

[1]. Kubota T, et al. Investigation of intracellular magnesium mobilization pathways I PC12 cells B simultaneous Mg-Ca fluorescent imaging. J Am Coll Nutr. 2004;23(6):742S-4S. [2]. Fujii T, et al. Design and synthesis of a FlAsH-type Mg2+ fluorescent probe for specific protein labeling. J Am Chem Soc. 2014;136(6):2374-2381.

PeptideDB

KMG-104

CAS: 852057-94-4 F: C23H11F2NO6 W: 435.33