| Bioactivity | KM04416, an isothiazolone derivative, is a potent glycerol-3-phosphate dehydrogenase (GPD2) inhibitor. KM04416 significantly inhibits PNT1A cell proliferation[1][2]. | ||||||||||||
| Invitro | KM04416 (20 µM; 48 小时) 对多种癌细胞系具有生长抑制作用[1]。 KM04416 (10 µM; 72小时) 显着抑制 PNT1A 细胞增殖[1]。 Cell Viability Assay[1] Cell Line: | ||||||||||||
| Name | KM04416 | ||||||||||||
| CAS | 26530-26-7 | ||||||||||||
| Formula | C12H11NO3S | ||||||||||||
| Molar Mass | 249.29 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Sehyun Oh, et al. Non-bioenergetic roles of mitochondrial GPD2 promote tumor progression. Theranostics. 2023 Jan 1;13(2):438-457. [2]. Gurmit Singh, et al. Mitochondrial FAD-linked Glycerol-3-phosphate Dehydrogenase: A Target for Cancer Therapeutics. Pharmaceuticals (Basel). 2014 Feb 11;7(2):192-206. |