| Bioactivity | KL044, a stabilizer of the clock protein cryptochrome (CRY) , is a potent chemical probe with a pEC50 value of 7.32, leading to the extension of the circadian period and repression of Per2 activity[1]. | ||||||||||||
| Target | pEC50: 7.32 | ||||||||||||
| Invitro | KL044 (0-3.7 μM; 8 h) effectively stabilizes the CRY1-LUC fusion protein without affecting the stability of LUC in the HEK293 stable cell line[1]. | ||||||||||||
| Name | KL044 | ||||||||||||
| CAS | 1801856-93-8 | ||||||||||||
| Formula | C21H14ClN3O | ||||||||||||
| Molar Mass | 359.81 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Jae Wook Lee, et al. Development of Small-Molecule Cryptochrome Stabilizer Derivatives as Modulators of the Circadian Clock. ChemMedChem. 2015 Sep;10(9):1489-97. |