| Bioactivity | KL-50 is a selective toxin toward tumors that lack the DNA repair protein O6-methylguanine-DNA-methyltransferase (MGMT), which reverses the formation of O6-alkylguanine lesions. KL-50 activates DNA damage response pathways and cycle arrest in MGMT-cells, independent of mismatch repair (MMR). KL-50 is promising for research of brain tumors that lack the DNA repair protein MGMT[1][2]. |
| CAS | 1161826-19-2 |
| Formula | C7H7FN6O2 |
| Molar Mass | 226.17 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Huseman ED, et al. Mechanism of Action of KL-50, a Candidate Imidazotetrazine for the Treatment of Drug-Resistant Brain Cancers. J Am Chem Soc. 2024 Jul 10;146(27):18241-18252. [2]. HERZON Seth, et al. Preparation of imidazotetrazine compounds and methods for treating cancers that are MGMT deficient regardless of MMR status. WO2023049806. 2022 September 22. |