| Bioactivity | KKII5 is a potent Lipoxygenase (LOX-1) inhibitor with an IC50 of 19 μM. KKII5 inhibits lipid peroxidation[1]. |
| Target | IC50: 19 μM (LOX-1) |
| Invitro | KKII5 与腔体的 HIS499 相互作用，通过在分子的苯环和 HIS499 的咪唑环之间形成一个 π-π 堆叠相互作用[1]。KKII5 (100 μM) 对脂质过氧化有明显抑制作用，抑制率达 98% [1]。 |
| Name | KKII5 |
| CAS | 6381-55-1 |
| Formula | C16H14N2S |
| Molar Mass | 266.36 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Georgiou N, et al. Thiocarbohydrazone and Chalcone-Derived 3,4-Dihydropyrimidinethione as Lipid Peroxidation and Soybean Lipoxygenase Inhibitors. ACS Omega. 2023 Mar 21;8(13):11966-11977. |