KIN1400_product_DataBase

Bioactivity	KIN1400 is a potent IRF3 activator. KIN1400 triggers IRF3-dependent innate immune antiviral genes (RIG-I, MDA5, IFIT1, and Mx1) and IFN-β expression. KIN1400 inhibits WNV and DV, two mosquito-borne members of the Flaviviridae and the genus Flavivirus. KIN1400 also inhibits HCV replication. KIN1400 induces innate antiviral immunity through a MAVS-IRF3 axis[1].
Invitro	KIN1400（0-20 μM，20 小时）可在 PMA 分化的 THP-1 细胞中以剂量依赖性方式诱导先天免疫基因 RIG-I (DDX58)、IFIT1 和 Mx1 的表达[1].KIN1400（0-20 μM，24 小时）在 HEK293 细胞中抑制 WNV RNA 水平呈剂量依赖性，2 μM KIN1400 足以实现 50% 或更高的 WNV RNA 水平抑制[1]。
Name	KIN1400
CAS	446826-86-4
Formula	C24H17F2N3O2S
Molar Mass	449.47
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Pattabhi S, et al. Targeting Innate Immunity for Antiviral Therapy through Small Molecule Agonists of the RLR Pathway. J Virol. 2015 Dec 16;90(5):2372-87.

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