Bioactivity | KIF18A-IN-15 (Compound Example 36) is a KIF18A inhibitor, available in two forms, EX36-A and its enantiomer EX36-B, with IC50s of 0.01-0.1 μM, respectively. EX36-A and EX36-B inhibit OVCAR-3 cells viability with IC50s of 0.01-0.1 μM and 0-0.01 μM, respectively. KIF18A-IN-15 can be used in tumor (e.g. colon, breast, lung) studies[1]. |
Invitro | EX36-A 和 EX36-B 抑制 OVCAR-3 细胞活力,IC50 分别为 0.01-0.1 μM 和 0-0.01 μM[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> KIF18A-IN-15 相关抗体: |
CAS | 3051552-64-5 |
Formula | C25H33F3N6O5S |
Molar Mass | 586.63 |
Transport | Room temperature in continental US; may vary elsewhere. |
Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Reference | [1]. Ding, et al. Inhibitors of kif18a and uses thereof. WO2024153217.WIPO, 2024-01-19. |