| Bioactivity | KHK-IN-3 (Example 1) is a ketohexokinase (KHK) inhibitor. KHK-IN-3 can be used in the study of kidney disease, nonalcoholic steatohepatitis (NASH), diabetes and heart failure. KHK is a rate-limiting enzyme and fructokinase involved in fructose metabolism. KHK catalyzes the phosphorylation of fructose to fructose-1-phosphate (FIP) at the expense of ATP. The lack of feedback inhibition of fructose metabolism triggers the accumulation of downstream intermediates such as lipogenesis, gluconeogenesis, and oxidative phosphorylation[1]. | ||||||||||||
| Name | KHK-IN-3 | ||||||||||||
| CAS | 2568608-48-8 | ||||||||||||
| Formula | C18H22F3N7O | ||||||||||||
| Molar Mass | 409.41 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Coates David Andrew, et al. Preparation of the disubstituted pyrazole compound and their medical applications. United States, US20200392118 A1. 2020-12-17. |
KHK-IN-3
CAS: 2568608-48-8 F: C18H22F3N7O W: 409.41
KHK-IN-3 (Example 1) is a ketohexokinase (KHK) inhibitor. KHK-IN-3 can be used in the study of kidney disease, nonalcoho
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