| Bioactivity | KH-CB20, an E/Z mixture, is a potent and selective inhibitor of CLK1 and the closely related isoform CLK4, with an IC50 of 16.5 nM for CLK1. KH-CB20 can also inhibit DYRK1A (IC50=57.8 nM) and CLK3 (IC50=488 nM)[1]. | ||||||||||||
| Invitro | KH-CB20 shows selectivity for CLK1 (IC50=16.5 nM) over DYRK1A (IC50=57.8 nM) and CLK3 (IC50=488 nM)[1]. | ||||||||||||
| Name | KH-CB20 | ||||||||||||
| CAS | 1354448-60-4 | ||||||||||||
| Formula | C15H13Cl2N3O2 | ||||||||||||
| Molar Mass | 338.19 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
|
||||||||||||
| Reference | [1]. Fedorov O, et, al. Specific CLK inhibitors from a novel chemotype for regulation of alternative splicing. Chem Biol. 2011 Jan 28;18(1):67-76. |
KH-CB20
CAS: 1354448-60-4 F: C15H13Cl2N3O2 W: 338.19
KH-CB20, an E/Z mixture, is a potent and selective inhibitor of CLK1 and the closely related isoform CLK4, with an IC50
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.