| Bioactivity | KG-655 is a small molecule compound that binds to the β-folded surface and internal cavity of ARNT PAS-B and interferes with its binding to the transcriptional coactivator TACC3. KG-655 can promote the homodimerization of ARNT PAS-B and has the potential to regulate multiple ARNT-mediated signaling pathways[1]. |
| Target | ARNT |
| CAS | 349-58-6 |
| Formula | C8H4F6O |
| Molar Mass | 230.11 |
| Appearance | 21°C 液体 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen) |
| Reference | [1]. Identification of Small Molecule Ligand Binding Sites On and In the ARNT PAS-B Domain |