KF-14124_product_DataBase

Bioactivity	KF-14124, an orally active organic nitrate, a long-acting vasodilator with highly selective venous dilating action. KF-14124 is used in the study for angina pectoris. KF-14124 shows good oral inhibition of lysine-vasopressin induced coronary vasospasm with a potency[1][2].
In Vivo	KF-14124 (0.3 mg/kg 经十二指肠给药) 在Propranolol (HY-B0573B)诱导的心力衰竭模型 (犬) 中，倾向于降低左心室舒张末期压 (LVEDP)，并且在大鼠中显示出对再灌注性心律失常的强效保护作用。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.
CAS	134186-26-8
Formula	C19H27N3O5S
Molar Mass	409.50
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. 1,4:3,6-Dianhydrohexitol nitrate derivatives. I. Synthesis and antianginal activity of alkylpiperazine derivatives. Chem Pharm Bull (Tokyo). 1993 Jun;41(6):1091-9. [2]. Giorgio Bertolini, et al. Overview: Recent Advances in Organic Nitrates. Current Opinion on Therapeutic Patents Volume 3, 1993 - Issue 10.

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