| Bioactivity | KDM5-C49 (KDOAM-20) hydrochloride is a potent and selective inhibitor of KDM5 demethylases, with IC50s of 40 nM, 160 nM, and 100 nM for KDM5A, KDM5B, and KDM5C enzymes, respectively. KDM5-C49 hydrochloride can be used for the research of cancer[1]. |
| Invitro | KDM5-C49 hydrochloride 渗透性差。将 KDM5-C49 的羧基转化为乙酯，得到具有细胞渗透性的前药（KDM5-C70）。 |
| Name | KDM5-C49 hydrochloride |
| Formula | C15H25ClN4O3 |
| Molar Mass | 344.84 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Horton JR, et, al. Structural Basis for KDM5A Histone Lysine Demethylase Inhibition by Diverse Compounds. Cell Chem Biol. 2016 Jul 21;23(7):769-781. [2]. Song YQ, et al. The role and prospect of lysine-specific demethylases in cancer chemoresistance. Med Res Rev. 2023 Apr 3. |
KDM5-C49 hydrochloride
CAS: F: C15H25ClN4O3 W: 344.84
KDM5-C49 (KDOAM-20) hydrochloride is a potent and selective inhibitor of KDM5 demethylases, with IC50s of 40 nM, 160 nM,
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.