| Bioactivity | KC01 is an effective inhibitor of ABHD16A, with IC50s of 90 nM for hABHD16A and 520 nM for mABHD16A. KC01 significantly reduces lyso-PSs, and decreases lyso-PS and LPS-induced cytokine production in mouse macrophages [1]. | |||||||||
| Target | 90 nM for hABHD16A and 520 nM for mABHD16A | |||||||||
| Invitro | KC01(0-20 μM; 30 min) 是 ABHD16A 的潜在抑制剂，其 IC50 0 --> KC01 相关抗体: Western Blot Analysis[1] Cell Line: | |||||||||
| Name | KC01 | |||||||||
| CAS | 1646795-59-6 | |||||||||
| Formula | C22H39NO3 | |||||||||
| Molar Mass | 365.55 | |||||||||
| Appearance | 固体 | |||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | |||||||||
| Storage |
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| Reference | [1]. Siddhesh S Kamat, et al. Immunomodulatory lysophosphatidylserines are regulated by ABHD16A and ABHD12 interplay. Nat Chem Biol 2015 Feb;11(2):164-71. |