KC 12291 hydrochloride_product_DataBase

Bioactivity	KC 12291 hydrochloride is an orally active blocker of voltage-gated sodium channel (VGSC). KC 12291 hydrochloride reduces the amplitude of sustained Na+ current to exert antiischemic activity. KC 12291 hydrochloride has significant cardioprotective effect in vitro and in vivo[1].
Invitro	KC 12291 hydrochloride (1 μM) 降低了大约 60 % 大鼠心室心肌细胞的 Na+ 电流峰[1] 。 0 --> KC 12291 hydrochloride 相关抗体:
In Vivo	KC 12291 hydrochloride (0.63 mg/kg，口服；1 次) 对麻醉兔模型有明显的抗缺血活性[1]。KC 12291 hydrochloride (60 mg/kg，口服) 在雌性和雄性小鼠中的血浆 Cmax 值分别为 1.3 和 1.4 μg/mL，血浆的 Tmax 值将近 2 小时[1]。 Animal Model:
Name	KC 12291 hydrochloride
CAS	181936-98-1
Formula	C22H28ClN3O3S
Molar Mass	449.99
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. John GW, et al. KC 12291: an atypical sodium channel blocker with myocardial antiischemic properties. Cardiovasc Drug Rev. 2004 Spring;22(1):17-26.

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