| Bioactivity | KBP-7018 is a tyrosine kinase-selective inhibitor. KBP-7018 has potent inhibitory effects on c-KIT, PDGFR, and RET with IC50 values of 10 nM, 7.6 nM and 25 nM, respectively. KBP-7018 can be used for the research of idiopathic pulmonary fibrosis[1]. |
| Target | IC50: c-KIT (10 nM), PDGFR (7.6 nM), and RET (25 nM). |
| Name | KBP-7018 |
| CAS | 1613437-66-3 |
| Formula | C31H30N4O5 |
| Molar Mass | 538.59 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Huang Z, et al. Discovery of Indolinone-Based Multikinase Inhibitors as Potential Therapeutics for Idiopathic Pulmonary Fibrosis. ACS Med Chem Lett. 2017 Sep 30;8(11):1142-1147. |