| Bioactivity | KAT8-IN-1 is a lysine (K) acetyltransferase 8 (KAT8) inhibitor, with IC50s of 141 μM (KAT8), 221 μM (KAT2B), 106 μM (KAT3B), respectively. KAT8 inhibits histone acetyltransferases (HATs), and could result in disease states, such as cancer or inflammatory diseases[1]. |
| Target | IC50: 141 μM (KAT8), 221 μM (KAT2B), 106 μM (KAT3B) |
| Invitro | KAT8-IN-1 (compound 19) losses anti-oxidant activity (EC50>1 mM)[1]. |
| Name | KAT8-IN-1 |
| CAS | 605-62-9 |
| Formula | C10H7NO3 |
| Molar Mass | 189.17 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen) |
| Reference | [1]. Wapenaar H, et al. The relevance of Ki calculation for bi-substrate enzymes illustrated by kinetic evaluation of a novel lysine (K) acetyltransferase 8 inhibitor. Eur J Med Chem. 2017 Aug 18;136:480-486. |