| Bioactivity | K783-0308 is a potent and selective dual inhibitor of FLT3 and MNK2 with IC50 values of 680 and 406 nM, respectively. K783-0308 inhibits the growth of MOLM-13 (IC50=10.5 µM) and MV-4-11 (IC50=10.4 µM) cells. K783-0308 promotes acute myeloid leukemia (AML) cell apoptosis and cell cycle arrests in the G0/G1 phase[1]. |
| Invitro | K783-0308 (MOLM-13, MV-4-11 cells) shows cytotoxic effect against MOLM-13 (IC50=10.5 µM) and MV-4-11 (IC50=10.4 µM) cells[1].K783-0308 (1, 3, 10, 30 µM) promotes AML cell apoptosis and cell cycle arrests in the G0/G1 phase[1]. Cell Cytotoxicity Assay[1] Cell Line: |
| Name | K783-0308 |
| CAS | 422554-29-8 |
| Formula | C21H23N3O |
| Molar Mass | 333.43 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |