| Bioactivity | K1586 is an amidine derivative that efficiently targets Chk1. K1586 enhances the degradation of Chk1 that sensitizes colorectal cancer cells to ionizing radiation. K1586 shows anticancer effects[1]. |
| Invitro | K1586 (0.001-100 μM; 72 小时) 以剂量依赖性方式降低细胞增殖[1]。K1586 (10-20 μM; 24 小时) 增加 S 期的相对长度，并显著增加 G2/M 期的长度[1]。 K1586 (10 μM; 12 小时) 以时间依赖性方式降低 Chk1 蛋白水平[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> K1586 相关抗体: Cell Proliferation Assay[1] Cell Line: |
| Formula | C18H18ClN3OS |
| Molar Mass | 359.87 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Hang Soo Kim, et al. Novel Amidine Derivative K1586 Sensitizes Colorectal Cancer Cells to Ionizing Radiation by Inducing Chk1 Instability. Int J Mol Sci. 2024 Apr 16;25(8):4396. |