| Bioactivity | K-7174 is an orally active proteasome and GATA inhibitor. K-7174 is a cell adhesion inhibitor. K-7174 induces cell apoptosis. K-7174 shows antitumor activities, it can be used for the research of cancer[1][2][3]. |
| Invitro | K-7174 (10 μM; 1 h) inhibits the adhesion by VCAM-1 and its ligand[1].K-7174 (1-30 μM; 1 h) dose-dependently suppresses the VCAM-1 expression with an IC50 value of 14 μM[1].K-7174 (1-30 μM; 1 h) dose-dependently suppresses the induction of VCAM-1 mRNA by TNFα with an IC50 value of 9 μM[1].K-7174 (10-20 μM; 24 h) dose-dependently rescues Epo production by Hep3B cells[2].K-7174 (2.5-30 μM; 24 h) inhibits the binding activity of GATA[2].K-7174 (0-25 μM; 72 h) inhibits MM cells growth and induces cell apoptosis[3]. Cell Viability Assay[3] Cell Line: |
| Name | K-7174 |
| CAS | 191089-59-5 |
| Formula | C33H48N2O6 |
| Molar Mass | 568.74 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |