| Bioactivity | K-252d is an indolocarbazole alkaloid found in Nocardiopsis. It is a PKC inhibitor that inhibits PKC isolated from rat brain (IC50=350 nM). It also inhibits calcium- and calmodulin-dependent phosphodiesterase isolated from bovine heart (IC50=46.2 μM). |
| CAS | 105114-22-5 |
| Formula | C26H23N3O5 |
| Molar Mass | 457.48 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Nakanishi, et al. K-252b, c and d, potent inhibitors of protein kinase C from microbial origin. J. Antibiot. (Tokyo) 39(8), 1066-1071 (1986). |