Justicidin B_product_DataBase

Bioactivity	Justicidin B is a potent anticancer lignan and proapoptotic agent. Justicidin B is also a bone resorption inhibitor, and has strong antiviral, fungicidal, antiprotozoal effects. Justicidin B significantly inhibits platelet aggregation[1][2][3].
Invitro	Justicidin B 抑制致病真菌烟曲霉 (MIC ≥ 1 μg/mL)、黄曲霉 (MIC ≥ 12 μg/mL) 和白色念珠菌 (MIC ≥ 4 μg/mL) 的生长，但对新型隐球菌和头状芽孢杆菌无效[1]。Justicidin B 还对罗得西亚布氏锥虫的锥体鞭毛体形式表现出很强的活性 (IC50 = 0.2 μg/mL)，对克氏锥虫 (IC50 = 2.6 μg/mL) 表现出中等活性[1]。Justicidin B 在 MDA-MB-231 和 MCF-7 乳腺癌衍生细胞系中表现出细胞毒活性和诱导细胞凋亡。两种细胞系的 24 小时处理增加了凋亡 DNA 片段化的水平。MDA-MB-231 细胞与 Justicidin B 的接触导致 NFkB 表达的浓度依赖性降低；而 MCF-7 的处理与该转录因子表达的强烈增加一致[2]。
Name	Justicidin B
CAS	17951-19-8
Formula	C21H16O6
Molar Mass	364.35
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.

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