Justicidin A_product_DataBase

Bioactivity	justicidin A is a nature product that could be isolated form Justicia procumbens. justicidin A decreases the level of Ku70 leading to translocation of Bax from the cytosol to mitochondria to induce apoptosis. justicidin A can be used in research of cancer[1].
Invitro	justicidin A (0-2.5 μM; 6 天) 抑制结直肠癌细胞的生长，对 HT-29、HCT 116、SiHa、MCF7 和 T24 细胞的 IC50 值分别为 0.110、0.400、0.020、1.540 和 0.004 μM[1]。justicidin A (0.75 和 5 μM; 0-72 h) 诱导结直肠癌细胞凋亡[1]。justicidin A (0.75 和 5 μM; 0-72 h) 诱导人结直肠癌细胞中 caspases 及其靶蛋白的裂解[1]。justicidin A (0.75 和 5 μM; 0-72 h) 损伤线粒体，并从线粒体释放 cyto c 和 Smac[1]。justicidin A (0.75 和 5 μM; 0-72 h) 降低 Ku70 水平，导致 Bax 从细胞质转位到线粒体[1]。 Cell Viability Assay[1] Cell Line:
Name	Justicidin A
CAS	25001-57-4
Formula	C22H18O7
Molar Mass	394.37
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.

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