| Bioactivity | Jervine (11-Ketocyclopamine) is a potent Hedgehog (Hh) inhibitor with an IC50 of 500-700 nM[1]. Jervine is a natural teratogenic sterodial alkaloid from rhizomes of Veratrum nigrum. Jervine has anti-inflammatory and antioxidant properties[2]. | ||||||||||||
| Invitro | Jervine (40 μM; 6, 12 and 24 hours) inhibits Akt phosphorylation[3]. Jervine (40 μM; 2 hours) inhibits NF-jB activation decreased COX-2 overexpression and induced apoptosis[3]. Western Blot Analysis[1] Cell Line: | ||||||||||||
| Name | Jervine | ||||||||||||
| CAS | 469-59-0 | ||||||||||||
| Formula | C27H39NO3 | ||||||||||||
| Molar Mass | 425.60 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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